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Dorothee Weihrauch Selected Research

Isoflurane

9/2015Isoflurane favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats.
7/2013Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia.
11/2011Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection.
9/2011Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning.
3/2010Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms.
2/2009Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
12/2006Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits.
8/2006Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase.
8/2006Extracellular signal-regulated kinases trigger isoflurane preconditioning concomitant with upregulation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in rats.
5/2006Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo.
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Dorothee Weihrauch Research Topics

Disease

23Infarction (Infarctions)
01/2020 - 12/2002
21Myocardial Infarction
09/2015 - 12/2002
12Ischemia
12/2021 - 07/2003
9Reperfusion Injury
09/2015 - 05/2004
9Coronary Occlusion
02/2009 - 03/2002
6Hyperglycemia
07/2013 - 05/2003
4Inflammation (Inflammations)
03/2020 - 09/2007
4Hypoxia (Hypoxemia)
11/2011 - 11/2005
2Pain (Aches)
05/2022 - 01/2010
2Immunoglobulin Light-chain Amyloidosis
06/2020 - 12/2017
2Diabetes Mellitus
03/2020 - 12/2017
2Fibrosis (Cirrhosis)
01/2016 - 03/2012
2Myocardial Ischemia (Ischemic Heart Diseases)
09/2015 - 07/2003
2Sickle Cell Anemia (Hemoglobin S Disease)
11/2013 - 09/2007
2Peripheral Nerve Injuries
09/2013 - 01/2010
2Pneumonia (Pneumonitis)
09/2010 - 09/2008
2Neuralgia (Stump Neuralgia)
01/2010 - 08/2009
1Hypersensitivity (Allergy)
05/2022
1Neuroma
05/2022
1Peripheral Arterial Disease
01/2022
1Necrosis
12/2021
1Amyloidosis
06/2020
1Heart Failure
01/2020
1Plasma Cell Neoplasms
12/2017
1Neoplasms (Cancer)
12/2017
1Hyperplasia
10/2015
1Vascular Remodeling
10/2015
1Type 2 Diabetes Mellitus (MODY)
10/2015
1Leukemia
11/2013
1Vasculitis (Vasculitides)
09/2013

Drug/Important Bio-Agent (IBA)

20IsofluraneFDA LinkGeneric
09/2015 - 12/2002
17triphenyltetrazoliumIBA
12/2021 - 12/2002
8Saline SolutionIBA
09/2007 - 05/2003
7Anesthetics (Anesthetic Agents)IBA
09/2015 - 04/2005
5Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2017 - 08/2006
5Proteins (Proteins, Gene)FDA Link
09/2015 - 05/2006
4Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
09/2015 - 02/2006
4Glucose (Dextrose)FDA LinkGeneric
07/2013 - 05/2003
4Reactive Oxygen Species (Oxygen Radicals)IBA
09/2011 - 05/2003
4HeliumIBA
10/2009 - 08/2008
4AtractylosideIBA
09/2008 - 12/2005
3LipidsIBA
01/2021 - 09/2010
3CollagenIBA
10/2015 - 09/2010
3Superoxides (Superoxide)IBA
11/2013 - 12/2002
3Apolipoprotein A-I (Apolipoprotein A1)IBA
07/2013 - 09/2007
3WortmanninIBA
09/2007 - 10/2005
3AngiostatinsIBA
09/2007 - 05/2004
31- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
05/2006 - 12/2005
3Blood Glucose (Blood Sugar)IBA
05/2004 - 05/2003
2salicylhydroxamic acid (SHAM)IBA
05/2022 - 05/2004
2EmulsionsIBA
01/2021 - 07/2017
2Doxycycline (Periostat)FDA LinkGeneric
06/2020 - 12/2017
2Peroxidase (Myeloperoxidase)IBA
03/2020 - 11/2013
2sapropterin (tetrahydrobiopterin)FDA Link
09/2015 - 03/2010
2Opioid Receptors (Opioid Receptor)IBA
10/2009 - 10/2005
2Naloxone (Narcan)FDA LinkGeneric
10/2009 - 10/2005
2Morphine (MS Contin)FDA LinkGeneric
10/2009 - 10/2005
2Nitric Oxide Synthase (NO Synthase)IBA
02/2009 - 09/2008
2arginine methyl esterIBA
02/2009 - 07/2005
2NG-Nitroarginine Methyl Ester (L-NAME)IBA
09/2008 - 08/2006
2Adenosine Triphosphate (ATP)IBA
08/2008 - 12/2005
22- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA
09/2007 - 08/2006
2Phosphotransferases (Kinase)IBA
09/2007 - 02/2006
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2006 - 07/2003
2Cyclosporine (Ciclosporin)FDA LinkGeneric
05/2006 - 12/2005
2Cytochromes c (Cytochrome c)IBA
11/2005 - 10/2005
2Matrix Metalloproteinases (MMPs)IBA
05/2004 - 05/2004
1AcetoneIBA
05/2022
1ameroidIBA
01/2022
1phospholipid emulsion soybean oil (Intralipid)IBA
01/2021
1ThiazolidinedionesIBA
01/2020
1Rosiglitazone (Avandia)FDA Link
01/2020
1Amyloid (Amyloid Fibrils)IBA
12/2017
1Immunoglobulin SubunitsIBA
12/2017
1Peptides (Polypeptides)IBA
01/2016
1Advanced Glycation End ProductsIBA
10/2015
1alagebriumIBA
10/2015
1OzoneIBA
09/2015
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
09/2015
1Guanosine Triphosphate (GTP)IBA
09/2015
1EnzymesIBA
09/2015
12,4-diaminohypoxanthineIBA
09/2015
1Tetradecanoylphorbol AcetateIBA
11/2013
1N-acetyllysyltyrosylcysteine amideIBA
11/2013
1Sigma-1 ReceptorIBA
09/2013
1IonsIBA
09/2013
1MetalsIBA
09/2013
1Collagen Type VIIBA
03/2012
1HexosaminesIBA
03/2012
1AcetylglucosamineIBA
03/2012
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
11/2011
1Aryldialkylphosphatase (Paraoxonase)IBA
09/2010

Therapy/Procedure

2Therapeutics
12/2017 - 01/2010
2Microspheres (Microsphere)
12/2007 - 06/2003
1Surgical Amputation (Amputations)
05/2022
1Tourniquets
12/2021
1Lasers (Laser)
12/2021
1Drug Therapy (Chemotherapy)
06/2020
1Induced Heart Arrest (Cardioplegia)
07/2017
1Stents
10/2015